By David Woolley, Visit Amazon's Adam Woolley Page, search results, Learn about Author Central, Adam Woolley,

ISBN-10: 1420043145

ISBN-13: 9781420043143

This sensible, undemanding, and informative textual content surveys uncomplicated ideas of toxicology. it's a useful consultant to comparing toxicity and comparable information, impending toxicity trying out and interpretation, and knowing the innovations of probability prediction and danger review and management.

A advisor to functional Toxicology:

  • examines tips on how to review a variety of teams of chemicals—pharmaceuticals, cosmetics, and agrochemicals
  • provides insights on toxicity selection, normality and naturality, prediction, and regulation

Two all-new chapters cover:

  • safety pharmacology
  • evaluation of alternative chemical classes
  • Show description

Read Online or Download A Guide to Practical Toxicology: Evaluation, Prediction, and Risk, Second Edition PDF

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Additional resources for A Guide to Practical Toxicology: Evaluation, Prediction, and Risk, Second Edition

Sample text

The study of the potatoes by dietary administration to rats concluded that there was significant hazard for consumers in the genetic modification and extended this conclusion to other genetically altered foods. However, the study was of short duration, used small numbers of animals and unrealistically high inclusion levels of the potatoes, which was probably a confounding factor in this study. In short, it was considered that the experiment was poorly designed, executed, and interpreted and not a suitable basis for drawing conclusions.

Where there is preexisting cirrhosis of the liver, hepatic function will differ significantly from normal. Damage in the liver inflicted by paracetamol has the effect of prolonging exposure to the drug. Where liver disease is associated with bilirubinaemia, drugs bound to plasma proteins may be displaced by bilirubin, markedly increasing the plasma concentration of free drug. For drugs such as phenytoin or warfarin, which are highly protein-bound and have steep dose–response curves, a small decrease Introduction to Toxicology: The Necessity of Measurement 23 in protein binding can more than double the amount of free drug available for pharmacological effect.

The use of rabbits or mice in bioassays for potency of various biological pharmaceutical preparations, such as insulin, has been greatly reduced by the use of more precisely targeted pharmacological or analytical tests. This is exemplified by the large reduction in numbers of biological tests described in the British Pharmacopoiea for 1993 in comparison with that for 1988. Replacement of animals in toxicological testing is inherently simpler if a specific endpoint is being investigated, whether pyrogen content or DNA damage.

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A Guide to Practical Toxicology: Evaluation, Prediction, and Risk, Second Edition by David Woolley, Visit Amazon's Adam Woolley Page, search results, Learn about Author Central, Adam Woolley,

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