By National Research Council, Division on Earth and Life Studies, Board on Environmental Studies and Toxicology, Committee on Toxicology, Committee on Acute Exposure Guideline Levels

ISBN-10: 0309127556

ISBN-13: 9780309127554

This e-book is the 7th quantity within the sequence "Acute publicity guide degrees for chosen Airborne Chemicals", and contains AEGLs for acetone cyanohydrin, carbon disulfide, monochloroacetic acid, and phenol. on the request of the dept of security, the nationwide examine Council has reviewed the suitable medical literature compiled via knowledgeable panel and proven Acute publicity guide degrees (AEGLs) for 12 new chemical substances. AEGLs characterize publicity degrees under which antagonistic well-being results aren't more likely to happen and are precious in responding to emergencies similar to unintentional or intentional chemical releases in the neighborhood, the place of work, transportation, the army, and for the remediation of infected websites. 3 AEGLs are licensed for every chemical, representing publicity degrees that bring about: striking yet reversible ache; long-lasting well-being results; and, life-threatening wellbeing and fitness affects.

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Additional resources for Acute Exposure Guideline Levels for Selected Airborne Chemicals, Volume 7

Example text

2. Animal Data Relevant to AEGL-1 During the first week of repeated 10-ppm 6-h exposure studies in rats, there was no sign of red nasal discharge in one study (Monsanto 1986a). The incidence of nasal discharge was not increased compared with concurrent control groups in two studies (Monsanto 1982b,c), but it was increased compared with the control group in a fourth study (Monsanto 1986b). No other adverse effects were reported in these four studies. 3. Derivation of AEGL-1 Human data on acetone cyanohydrin relevant for the derivation of AEGL1 are lacking.

Since no definitive reports on the odor threshold of acetone cyanohydrin were located in the literature, no level of distinct odor awareness (LOA) was derived. The derivation of AEGL-2 values was based on the facts that acetone cyanohydrin decomposes spontaneously to HCN and acetone and that the systemic toxicity of acetone cyanohydrin is due to free cyanide. Once absorbed, a dose of acetone cyanohydrin behaves in a manner identical to that of its molar equivalent in absorbed free cyanide. It is appropriate to apply the AEGL-2 values (on a ppm basis) derived for HCN (NRC 2002) to acetone cyanohydrin.

9 ppm for 6 h/d, 5 d/wk for 4 weeks, which caused signs of irritation, while the next higher concentration produced respiratory distress, prostration, convulsions and tremors, Monsanto [1986a]). The derivation of AEGL-3 values was based on the facts that acetone cyanohydrin decomposes spontaneously to HCN and acetone and that the systemic toxicity of acetone cyanohydrin is due to free cyanide. Once absorbed, a dose of 16 Acute Exposure Guideline Levels acetone cyanohydrin behaves in a manner identical to that of its molar equivalent in absorbed free cyanide.

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Acute Exposure Guideline Levels for Selected Airborne Chemicals, Volume 7 by National Research Council, Division on Earth and Life Studies, Board on Environmental Studies and Toxicology, Committee on Toxicology, Committee on Acute Exposure Guideline Levels


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