By Shayne C. Gad
Acute toxicology checking out presents the 1st defensive line opposed to very likely risky chemical substances. This booklet is a whole and useful advisor to carrying out and reading all regulatory required and customary acute toxicity assessments. It offers certain protocols for the entire universal attempt designs and stories their improvement and pursuits. Acute Toxicology trying out, moment Edition will curiosity not just staff within the pharmaceutical undefined, but additionally researchers and scholars in toxicology and public health.
* Over a hundred tables summarizing and reading results
* entire insurance of all significant try out designs and their barriers and advantages
* present prestige of other try designs and versions
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Extra resources for Acute Toxicology Testing
Russell, W. M. , and Burch, R. L. (1959). The Principles of Humane Experimental Technique. Methuen, London. CHAPTER 3 Tests for Dermal Irritation and Corrosion Evaluation of materials for their potential to cause dermal irritation and corrosion due to acute contact has been common for industrial chemicals, cosmetics, agricultural chemicals, and consumer products since at least the 1930s (generally, pharmaceuticals are only evaluated for dermal effects if they are to be administered topically--and then by repeat exposure tests, which will not be addressed here).
39 with the other hand. The patch containing the test sample is then carefully placed into position onto the skin by raising the remaining three edges with tape dorsally until they are completely secured. 5 ml of physiological saline. If the test substance is a liquid, a patch is applied and secured to the appropriate skin site. 5 ml of test substance to the patch. If the test substance is a fabric, a 1 • 1-in. square sample is cut and placed on a patch. The test substance patch is placed on the appropriate skin site and secured.
Skin sites that are in the telogen phase (resting stage of hair growth) are used; those skin sites that are in the anagen phase (stage of active growth, indicated by the presence of a thick u n d e r c o a t or hair) are not used. 38 Acute Toxicology Testing B. Study procedure 1. As many as four areas of skin, two on each side of the rabbit's back, can be utilized for sites of administration. 2. Separate animals are not required for an untreated control group. Each animal serves as its own control.
Acute Toxicology Testing by Shayne C. Gad