By Keith Green (auth.), Keith Green, Henry F. Edelhauser, Robert B. Hackett, David S. Hull, David E. Potter, Ramesh C. Tripathi (eds.)

ISBN-10: 146137720X

ISBN-13: 9781461377207

ISBN-10: 1461559375

ISBN-13: 9781461559375

This quantity represents the court cases of the 5th Congress of the overseas Society of Ocular Toxicology (ISOT), which used to be held on the Grove Park lodge and hotel in Asheville, North Carolina, October 13-17, 1996. we're extremely joyful to offer this quantity to the ophthalmic group, particularly people with an important curiosity in ocular toxicol­ ogy. The 5th Congress used to be built round issues on the subject of ocular drug metabolism, the ocular pathophysiological results of nitric oxide, govt concerns when it comes to using replacement tools for toxicity checking out, and a workshop that encompassed comparisons of either in vitro as opposed to in vivo versions in addition to varied animal types. the end result of this congress, embodied during this quantity, is a contribution to the methodologies at the moment hired or below improvement and to numerous drug or actual results on various ocular tissues. whereas the point of interest of this court cases is on ocular results of gear or different fabrics, a few of the contributions take care of issues that experience a wider curiosity. The workshop in regards to the use of other version structures and the alternative of the simplest animal version for drug checking out covers a variety of pursuits that ex­ has a tendency some distance past particular ocular results. this is often very true within the region of other tools and within the collection of the easiest animal version for exam of other disorder entities.

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This process would lead to further interaction between cytoplasmic proteins or between intracellular proteins and membrane proteins to form additional disulfide bridges. Glycation and other covalent crosslinking may also occur further potentiating the formation of HMW aggregates and the cascading events of protein insolubilization, light scattering and cataract formation.

3. Davis KL, Conners MS, Dunn MW, Schwartzman ML. Induction of corneal epithelial cytochrome P450 arachidonate metabolism by contact lens wear. Invest Ophthalmol Vis Sci 1992;33:291-297. 4. Conners MS, Stoltz RA, Webb SC, Rosenberg J, Dunn MW, Abraham NG, Schwartzman ML. A closed eye contact lens model of corneal inflammation. Part I: Increase synthesis of cytochrome P450 arachidonic acid metabolism. Invest Ophthalmol Vis Sci 1995;36:828--840. 5. Conners MS, Stoltz RA, Davis KL, Dunn MW, Abraham NG, Levere RD, Schwartzman ML.

Metals as regulators of heme metabolism. Science 1977; 198: 1215-1221. 20 M. L. Schwartzman 121. Maines MD, Kappas A. Studies on the mechanism of induction of heme oxygenase by cobalt and other metal ions. Biochem J 1976; 154: 125-131. 122. Abraham NG, Lin H-C, Schwartzman ML, Levere RD, Shibahara S. The physiological significance of heme oxygenase. Int J Biochem 1988; 20:543-588. 123. Schwartzman ML, Abraham NG, Carroll MA, Levere RD, McGiff Jc. Regulation of arachidonic acid metabolism by cytochrome P450 in rabbit kidney.

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Advances in Ocular Toxicology by Keith Green (auth.), Keith Green, Henry F. Edelhauser, Robert B. Hackett, David S. Hull, David E. Potter, Ramesh C. Tripathi (eds.)

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