By National Research Council, Division on Earth and Life Studies, Commission on Life Sciences, Board on Environmental Studies and Toxicology, Committee on Biologic Markers, Subcommittee on Immunotoxicology
Are environmental pollution threatening the human immune approach? Researchers are speedily impending definitive solutions to this question, by using biologic markers - subtle evaluate instruments which could revolutionize detection and prevention of convinced illnesses. This quantity, 3rd in a chain on biologic markers, specializes in the human immune process and its reaction to environmental toxicants. The authoring committee presents path for carrying on with improvement of biologic markers, with concepts for making use of markers to immunotoxicology in people and prompt outlines for scientific and box reviews. This entire, up to date quantity should be useful to experts in toxicology and immunology and to biologists and investigators taken with the advance of biologic markers.
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Additional info for Biologic Markers in Immunotoxicology
Choosing among multiple markers requires attention to the appropriate statistical approaches that assist in the determination of whether the markers are statistically independent of one another. The complex interactions of the immune system require that a judgment be made of whether immunologic markers are biologically independent and should be treated as statistically independent or statistically correlated. Confounding factors can be controlled in epidemiologic study designs by restriction or matching and in analyses by stratification or multivariate methods.
The variation in age groups is particularly important and can often be controlled for epidemiologic studies. The neuropsychologic-immune relationship must be considered an important variable in analyzing immune-system markers, especially in situations where the threat or effect of environmental exposure can subject study groups to greater stress than control groups experience. Under such conditions, assessment of stress should be an essential component of study design. The importance of controlling for these factors and others known to influence the immune system in any particular study will depend on the study design and the populations involved.
The concentration of IgA and IgG in human serum increases in older blood donors; serum IgM decreases (Buckley and Dorsey, 1970). , 1979; Hausman and Weksler, 1985). These antibodies might contribute to the deregulation of the immune system that accompanies aging. It is important in evaluating age-related immunotoxic effects to distinguish between an alteration in the immune response that causes shortened survival and an alteration in the immune response that results from factors that lead to reduced survival.
Biologic Markers in Immunotoxicology by National Research Council, Division on Earth and Life Studies, Commission on Life Sciences, Board on Environmental Studies and Toxicology, Committee on Biologic Markers, Subcommittee on Immunotoxicology