By Jerry N. Blancato, Robert N. Brown, Curtis C. Dary, Mahmoud Abbas Saleh
content material: dating of biomarkers of publicity to probability review and hazard administration / Curtis C. Dary, James J. Quackenboss, Charles H. Nauman, and Stephen C. Hern --
Proposed use of human publicity biomarkers in environmental laws : poisonous components keep watch over Act / Larry L. Needham --
using reference diversity concentrations in environmental overall healthiness investigations / Robert H. Hill, Jr., Susan L. Head, Sam Baker, Carol Rubin, Emilio Esteban, Sandra L. Bailey, Dana B. Shealy, and Larry L. Needham --
attainable biomarkers for assessing overall healthiness hazards in weak contributors uncovered to agrochemicals with emphasis on constructing international locations / Abdel Khalek H. El-Sebae, Zaher A. Mohamed, Fawzia Abdel Rahman, and Alaa Kamel --
Blood cholinesterase job : inhibition as a hallmark of difficult impact / S. Padilla, L. Lassiter, okay. Crofton, and V.C. Moser --
Neurotoxic esterase inhibition : predictor of strength for organophosphorus-induced not on time neuropathy / Marion Ehrich --
elevated urinary excretion of xanthurenic acid as a biomarker of publicity to organophosphorus pesticides / Josef Seifert --
Serum protein profile : a potential biomarker for publicity to pesticides / Mahmoud Abbas Saleh, Mohamed Abou Zeid, Zaher A. Mohamed, and Fawzia Abdel Rahman --
Breast milk as a biomarker for tracking human publicity to environmental pollution / Mahmoud Abbas Saleh, Abdel Moneim Afify, Awad Ragab, Gamal El-Baroty, Alaa Kamel, and Abdel Khalek H. El-Sebae --
Carnitine and its esters as strength biomarkers of environmental-toxicological publicity to nongenotoxic tumorigens / John E. Garst --
L-carnitine as a detoxicant of nonmetabolizable acyl coenzyme A / L.L. Bieber, Z.H. Huang, and D.A. Gage --
using human 101L cells as a biomarker, P450 RGS, for assessing the capability danger of environmental samples / Jack W. Anderson, Kristen Bothner, David Edelman, Steven Vincent, Tien P. Vu, and Robert H. Tukey --
box program of fluorescence-based catalytic assays for measuring cytochrome P450 induction in birds / J.A. Davis, D.M. Fry, and B.W. Wilson --
preliminary effects for the inductively coupled plasma-mass spectrometric choice of hint components in organs of striped bass from Lake Mead, U.S.A. / Vernon Hodge, Klaus Stetzenbach, and Kevin Johannesson --
Aquatic toxicity of chemical agent simulants as made up our minds via quantitative structure-activity relationships and acute bioassays / N.A. Chester, G.R. Famini, M.V. Haley, C.W. Kurnas, P.A. Sterling, and L.Y. Wilson --
Use of a a number of pathway and multiroute physiologically dependent pharmacokinetic version for predicting organophosphorus pesticide toxicity / James B. Knaak, Mohammed A. Al-Bayati, Otto G. Raabe, and Jerry N. Blancato --
Use of spot urine pattern leads to physiologically established pharmacokinetic modeling of absorbed malathion doses in people / Michael H. Dong, John H. Ross, Thomas Thongsinthusak, and Robert I. Krieger --
Symbolic suggestions of small linear physiologically established pharmacokinetic versions invaluable in threat overview and experimental layout / Robert N. Brown --
comparability of symbolic, numerical zone below the focus curves of small linear physiologically established pharmacokinetic versions / Blaine L. Hagstrom, Robert N. Brown, and Jerry N. Blancato.
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Additional resources for Biomarkers for Agrochemicals and Toxic Substances. Applications and Risk Assessment
J. N. Engl. J. Med. 1991, 324:212-218. 15. G. J. Med. 1983, 308:373-1377. 16. D. JAMA 1994, 272:284-291. 17. C. JAMA 1994, 272:277-283. 18. ; Perritt, R. Enivron. Res. 1987, 43:2990-307. 19. G. Jr. Anal. Chem. 1992, 64:1021-1029. 20. V. J Anal. Toxicol. 1995, 19:187-191. 21. H. J. Environ Health Persp. 1995, 103(3):89-94. 22. V. Clin. Chem. 1994, 40:1401-1404. 23. H. L. Arch. Environ. Health 1995, 50:277-280. 24. L. Int. Arch. Environ. Health 1994, 47:1-5. 25. A. Arch. Environ. Health 1994, 49:402-409.
HILL ET AL. Use of Reference Range Concentrations 43 reference range as normal or expected. Concentrations greater than the 95th percentile are considered elevated- indicating probable overt exposure to a toxicant that results in that residue or metabolite in urine. In Lorain County, 78% of the methyl parathion-exposed residents had PNP concentrations greater than or equal to the 95th percentile concentration of the reference range. Clearly the majority of residents living in homes sprayed with methyl parathion had greater than normal exposure to this pesticide.
We have been involved in several other studies involving possible exposure to pesticides that used the reference range concentrations for pesticide residues or metabolites as a basis for comparison. ; ACS Symposium Series; American Chemical Society: Washington, DC, 1996. 3. HILLETAL. Use of Reference Range Concentrate 45 Figure 2. Frequency distribution plots of urinary p-nitrophenol (PNP) concentrations in the reference range population [n=974], Lorain County, Ohio residents [n=131], selected pesticide workers [n=23] (10), and selected persons who suffered pesticide poisonings [n=23] (9).
Biomarkers for Agrochemicals and Toxic Substances. Applications and Risk Assessment by Jerry N. Blancato, Robert N. Brown, Curtis C. Dary, Mahmoud Abbas Saleh