By Ronald P. Rubin

ISBN-10: 1468442171

ISBN-13: 9781468442175

ISBN-10: 1468442198

ISBN-13: 9781468442199

Since the book of my past monograph in 1974, very important development has been made within the huge sector of calcium examine, partic­ ularly because it relates to secretory phenomena. the numerous develop in technique, whereas widening the scope of our wisdom, has prompted examine during this specific region to turn into an increasing number of really good. It has, for this reason, turn into more and more tricky for researchers to think about and overview paintings outdoors their very own components of specialization and to com­ prehend the sector from a wide point of view. whereas many helpful re­ perspectives at the significance of calcium in mobile functionality are being professional­ duced, they've got now not tried to tug jointly the entire current wisdom right into a extra normal narrative. This quantity brings jointly experimental info and theories from varied resources, and makes an attempt to synthesize right into a wide conceptual framework the large quantity of specialised details that almost immediately exists within the common quarter of cal­ cium metabolism and the secretory approach. it really is very unlikely in a e-book of this size to debate particular references intimately and nonetheless continue clarity, so generalizations has to be made.

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Moreover, lowering the sodium concentration of the medium bathing isolated neurohypophyses augments secretion but does not enhance calcium entry (Douglas and 24 CHAPTER 1 Poisner, 1964a). Therefore, the relationship between ionic events cannot be simply viewed as a competition for membrane or channel binding sites prior to entry into the cell. Moreover, the laboratory demonstration of cations competing for the same binding sites does not signify that this competition is physiologically relevant.

While an introductory chapter is not the appropriate place to discuss the comparative effects of each of the divalent cations in the various secretory systems, it is important to emphasize that such an approach has been fruitful in gaining information as to the nature of the calciumreceptive system, particularly in secretory cells. Thus, in most secretory systems studied, strontium and barium have been found to substitute for calcium, whereas magnesium is inhibitory. The commonality of cation effects on the secretory process and on the contractile mechanism suggests that these two fundamental biological processes possess certain fundamental similarities.

Alternatively, the effects of verapamil and D-600 may be the result of a "local anesthetic" effect, implying a nonspecificity of action. So not only should the use of these agents on nonexcitable secretory cells be discouraged, but perhaps there should even be some concern for indiscriminately utilizing them on excitable secretory cells, particularly when their relative lack of potency and selectivity is apparent. 2. Lanthanum and Other Polyvalent Cations The organic calcium antagonists block calcium-dependent effects by an action on the voltage-dependent calcium channels.

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Calcium and Cellular Secretion by Ronald P. Rubin


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