By Raphael Mechoulam
Only many years in the past the endocannabinoid process used to be unknown. at the present time we're acutely aware that endocannabinoids are all in favour of a number of the services of the mammalian physique - in neuroprotection, urge for food and suckling, discomfort, copy, nervousness, reminiscence, bone formation and so forth. This quantity provides an up to date photograph of a few of the foremost fields of endocannabinoid examine. It summarizes the activities of the endocannabinoids on a number of physiological platforms and opens new healing home windows to a good number of diseases.
The first bankruptcy, at the use of hashish in India, may be considered as an expression of because of the natural practitioners, who for hundreds of years handed at the scientific traditions linked to the drug. The bankruptcy on chemistry is a brief precis of lively plant, artificial and endogenous cannabinoids being investigated this day, a lot of that are pointed out later within the booklet. Cannabidiol is an strange cannabinoid - it doesn't bind to the recognized receptors and but exerts a number of results. accordingly a bankruptcy is dedicated to it. extra chapters care for the endocannabinoid process and the endocannabinoids in a number of stipulations and physiological platforms. The concluding bankruptcy describes the examine performed on Sativex®, a standardized plant extract, presently to be brought in Canada as a drug for a number of sclerosis.
The meant viewers is drug researchers (medicinal chemists, pharmacologists, clinicians), neuroscientists, physiologists, and clinicians attracted to the influence of the endocannabinoid approach in a number of physiological systems.
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Extra resources for Cannabinoids as therapeutics
Schering Corp. (US): WO2004000807. 108 Kozlowski J A, Shih N Y, Lavey B J, Rizvi R K, Shankar B B, Spitler J M, Tong L, Wolin R, Wong M K (2004) Cannabinoid receptor ligands. Schering Corp. (US): WO2004014825. 109 Page D, Walpole Ch, Yang H (2004) Preparation of benzimidazolecarboxamides as CB2 receptor agonists for treating pain and other disorders. , Lai, X Z, Lu D (2004) Preparation of novel biphenyl and biphenyl-like cannabinoids with binding affinities for the CB1 and CB2 cannabinoid receptor.
The compounds exhibit a range of selectivities for CB2 over CB1. 309 nM for the CB1 and CB2 receptors, respectively. This compound produced dose-dependent anti-nociception to thermal stimulus in rats. The compound reduced locomotor activity in rats after intravenous administration, an effect attributed to activation of the CB1 receptor. Structure 16 A series of aromatic CB2 agonists has been disclosed by the Schering-Plough Research Institute [107, 108]. The compounds are reported to have anti-inflam- Cannabinoid chemistry: an overview 37 matory and immunomodulatory activities, and to be active in cutaneous T cell lymphoma, diabetes mellitus and other indications.
The patent application refers to the compound as having CB2 agonist activity. 5 mg/kg. Structure 15 The University of Connecticut has disclosed a series of indazole derivatives that have been found to act as agonists of cannabinoid receptors . The compounds exhibit a range of selectivities for CB2 over CB1. 309 nM for the CB1 and CB2 receptors, respectively. This compound produced dose-dependent anti-nociception to thermal stimulus in rats. The compound reduced locomotor activity in rats after intravenous administration, an effect attributed to activation of the CB1 receptor.
Cannabinoids as therapeutics by Raphael Mechoulam