By Curtis Klaassen

The main depended on all-in-one review of the biomedical and environmental features of toxicology--NOW extra whole, updated, and in complete color
The worlds best and so much authoritative textbook on poisons has extra to provide students,toxicologists, and pharmacologists than ever sooner than. Now in complete colour, and carefully revised, the 8th version of Casarett & Doulls TOXICOLOGY: the fundamental technology of toxins not just gives you a entire evaluation of the fundamental parts of toxicology, it deals the main up to date, revealing, and in-depth examine the systemic responses of poisonous substance to be had anywhere.
Combined with the newest considering by way of the fields best students plus sturdy insurance of normal rules, modes of motion, and chemical-specific toxicity, this landmark textual content maintains to set the traditional for toxicology references.
NEW to the 8th Edition
- FULL-COLOR layout to permit for a clearer interpretation of the fundamental parts of toxicology featured in the course of the text
- improved tables, illustrations, and different visuals are up-to-date with cutting-edge criteria that makes this version much more present and relevant
- NEW CHAPTERS contain «Toxic results of energy» and «Toxic results of Nanoparticles»

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Additional info for Casarett & Doull's Toxicology The Basic Science of Poisons, Eighth Edition

Sample text

Some effects are deleterious and others are not. In therapeutics, for example, each drug produces a number of effects, but usually only one effect is associated with the primary objective of the therapy; all the other effects are referred to as undesirable or side effects of that drug for that therapeutic indication. However, some of these side effects may be desired for another therapeutic indication. For example, the “first-generation” antihistamine diphenhydramine (Benadryl) is effective in reducing histamine responses associated with allergies, but it readily enters the brain and causes mild central nervous system (CNS) depression (drowsiness, delayed reaction time).

The alternative to local effects is systemic effects. Systemic effects require absorption and distribution of a toxicant from its entry point to a distant site at which deleterious effects are produced. Most substances except highly reactive materials produce systemic effects. For some materials, both effects can be demonstrated. For example, tetraethyl lead produces effects on skin at the site of absorption and then is transported systemically to produce its typical effects on the CNS and other organs.

In risk assessment, mechanistic data may be very useful in demonstrating that an adverse outcome (eg, cancer, birth defects) observed in laboratory animals is directly relevant to humans. For example, the relative toxic potential of organophosphorus (OP) insecticides in humans, rodents, and insects can be accurately predicted on the basis of an understanding of common mechanisms (inhibition of acetylcholinesterase) and differences in biotransformation for these insecticides among the different species.

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Casarett & Doull's Toxicology The Basic Science of Poisons, Eighth Edition by Curtis Klaassen

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