By Joseph J. Stephanos

ISBN-10: 1118448529

ISBN-13: 9781118448526

ISBN-10: 1118470443

ISBN-13: 9781118470442

ISBN-10: 1118801490

ISBN-13: 9781118801499

ISBN-10: 1118801520

ISBN-13: 9781118801529

ISBN-10: 111880158X

ISBN-13: 9781118801581

ISBN-10: 1118802233

ISBN-13: 9781118802236

ISBN-10: 1322007624

ISBN-13: 9781322007625

Addresses the total gamut of questions in metalloprotein science

Formatted as a question-and-answer consultant, this booklet examines all significant households of steel binding proteins, proposing our most modern realizing in their structural, physicochemical, and practical homes. furthermore, it introduces new and rising clinical functions of metalloproteins. Readers will realize either the underlying chemistry and biology of this significant zone of analysis in bioinorganic chemistry.

Chemistry of Metalloproteins incorporates a development block technique that permits readers to grasp the fundamentals after which develop to extra refined issues. The publication starts with a basic advent to bioinorganic chemistry and metalloproteins. subsequent, it covers:

  • Alkali and alkaline earth cations
  • Metalloenzymes
  • Copper proteins
  • Iron proteins
  • Vitamin B12
  • Chlorophyll

Chapters are richly illustrated to assist readers comprehend the entire chemical techniques that govern the organic motion of metalloproteins. additionally, every one bankruptcy ends with an inventory of recommended unique study articles and stories for additional research of person topics.

Presenting our most present knowing of metalloproteins, Chemistry of Metalloproteins is suggested for college students and researchers in coordination chemistry, biology, and medicine.

Each quantity of the Wiley sequence in Protein and Peptide technological know-how addresses a selected aspect of the sphere, reviewing the most recent findings and offering a large variety of views. The volumes during this sequence represent crucial examining for biochemists, biophysicists, molecular biologists, geneticists, mobile biologists, and physiologists in addition to researchers in drug layout and improvement, proteomics, and molecular drugs with an curiosity in proteins and peptides.

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Additional info for Chemistry of metalloproteins : problems and solutions in bioinorganic chemistry

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Natl. Acad. Sci. USA, 77, 6371–6375 (1980). SUGGESTIONS FOR FURTHER READING Texts on Biochemistry 1. J. J. R. F. da Silva and R. J. P. Williams, Biological Chemistry of Elements, Oxford University Press, New York (1991). 2. L. Stryer, Biochemistry, Freeman, New York (1995). 3. D. Voet and J. G. Voet, Biochemistry, Wiley, New York (1995). SUGGESTIONS FOR FURTHER READING 29 4. Advances in Protein Chemistry, Academic Press, New York. 5. P. D. , Academic, New York (1970–1986). 6. H. , Academic, New York, vol.

The selective distribution of cations inside and outside the cell and breakdown of this selectivity can act as a trigger for some biological events. 2. As principal biological cations with Cl , provide the ionic strength (μ ˆ Σ mi zi 2 , where mi is the molality (mol/kg) and z is the charge of positive or negative ions), which defines:  The operating environment for biological macromolecules (proteins, polysaccharides, and nucleic acids)  The conformations of these macromolecules 3. , inside vs.

There will be a transfer of [Cl ] from the other membrane side to the protein side. Protein Pr cannot diffuse from the left-hand-side (LHS) to the RHS, so to keep electrical neutrality; K+ diffuses with Cl to the LHS. Chemical potential must be equal on both sides of the membrane at equilibrium. This requires that the product [K+][Cl ] must have equal values on both sides of the membrane. Therefore, the [K+] gradient developed. [K+] is not equal on both sides of the membrane, [K+]LHS > [K+]RHS, and opposes the [Cl ] gradient.

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Chemistry of metalloproteins : problems and solutions in bioinorganic chemistry by Joseph J. Stephanos


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