By Frederick J. de Serres Ph.D. (auth.), Frederick J. De Serres, Michael D. Shelby (eds.)
Frederick J. de Serres, Ph. D. place of work of the affiliate Director for Genetics nationwide Institute of Environmental health and wellbeing Sciences learn Triangle Park, North Carolina (U. S. A. ) 27709 The Workshop on Comparative Chemical Mutagenesis was once orga nized to start the method of challenge id and backbone relating our must assessment the information on try chemical compounds bobbing up from assays for mutagenic job on laboratory organisms. long ago, facts on chemical mutagens has been generated and released within the medical literature on a kind of random foundation. person chemical compounds take pleasure in a quick interval of "popularity" that ends up in a burst of courses within the similar or occasionally similar assay platforms. The incompleteness of the information base, in lots of of those situations, makes comparative mutagenesis tough or very unlikely. In our makes an attempt to check the genetic results of a given chemical over quite a lot of assay platforms, we're frequently drawn to making quantitative in addition to qualitative compari sons. To restate the 1st comparability: is the chemical lower than ques tion a susceptible, reasonable or powerful mutagen over quite a lot of assay systems--or then again, does the extent of reaction fluctuate markedly? To make the second one comparability, what's wanted is details at the spectrum of genetic adjustments produced in addition to even if this spectrum is constant over a variety of organisms.
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Mutagenicity of ethylenimine in the standard plate incorporation assay on~. typhimurium TA1535. Spontaneous revertant colonies have been subtracted. 7. Ethyl Methanesulfonate Ethyl methanesulfonate is a direct-acting mutagen in Salmonella, reverting the missense tester strains TA1535 and TAlOO (Table 6, Fig. 7). This compound has not been tested in the presence of S-9 or on the frameshift tester strain TA1537, although it is unlikely that this strain would be reverted by this chemical. ICR-170 ICR-170 is a direct-acting mutagen in Salmonella, reverting the frameshift tester strain TA1537 (Table 6, Fig.
U'1 J: """ :lJ m -I » "'0 (') '" Salmonella/MICROSOME MUTAGENICITY TEST 53 Excision repair is required for mutagenesis with mitomycin C in Escherichia coli (41), and it has been suggested that mutation can be detected only if potentially lethal cross links are broken by the excision repair system (41,42). We are considering introducing one of these strains for the detection of crosslinking agents. g) Figure 9. Mutagenicity of METEPA in the standard plate incorporation assay on~. typhimurium TAlOO.
Weak activity is observed with the frameshift tester strain TA1537. Czygan et al. (40) tested MNNG in the presence of human liver micro somes and have shown that the mutagenic activity is decreased. This decrease in activity is dependent on the presence of an NADPH generating system. While MNNG gives rise to alkylating intermediates nonenzymatically, little information is available concerning the metabolism of this compound by the microsomal enzymes. It would be of interest to further examine the relationship between enzymatic deactivation and mutagenicity in Salmonella.
Comparative Chemical Mutagenesis by Frederick J. de Serres Ph.D. (auth.), Frederick J. De Serres, Michael D. Shelby (eds.)