By Rainer Spanagel, Karl F. Mann

ISBN-10: 3764302143

ISBN-13: 9783764302146

ISBN-10: 3764373059

ISBN-13: 9783764373054

The sector of biomedical study on alcoholism has constructed at an brilliant pace in recent times. this present day, new drugs and therapy suggestions can be found and new leads are at the moment validated in multi-center trials. This e-book provides a complete assessment approximately diverse neurotransmitter/peptide structures excited about yearning and relapse habit and significantly describes the scientific software of recent anti-craving and anti-relapse compounds. The editors - a preclinical researcher and a scientific researcher, including one of the most unusual specialists within the box - compiled the newest to be had preclinical and medical info, delivering a radical photograph on smooth relapse prevention. absolutely, this publication units out to supply an all-encompassing assessment in regards to the subject, on the way to be of curiosity to the preclinical researcher, the clinician in addition to to the sufferer who desires to examine extra.

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Extra resources for Drugs for Relapse Prevention of Alcoholism, 2005

Example text

Efforts to minimize How to measure relapse in humans 29 measurement reactivity include recording more than one behavior [32] and limiting recording to once a day [33]. In a series of daily process studies, including studies of heavy drinkers, we [18, 23, 34] found no significant evidence of trending or temporal changes in within-person associations that might signal measurement reactivity. Similarly, Hufford et al. [35] reported that electronic monitoring via palmtop computers appeared to show no noticeable reactivity effects.

Dorus et al. [54] conducted the largest and most methodologically sophisticated study of lithium for alcoholism treatment. R. Kranzler and H. Tennen recruited as inpatients and stratified on the basis of a lifetime history of depression. The outcomes included total abstinence, number of days of drinking, number of alcohol-related hospitalizations, change in the rating of alcoholism severity and change in the severity of depression. These measures were obtained at 4-week intervals by interviewing the patient and a collateral informant.

The rationale for choosing this measure was that it is a good predictor of acute alcohol-related problems. Furthermore, use of abstinence as a categorical measure of treatment outcome is limited by the small number of patients who are able to achieve it over an extended period of time and by its inability to show improvement over time. How to measure relapse in humans 35 Abstinence (though traditionally viewed as the most appropriate goal of alcohol treatment [59]), is not a suitable treatment goal for harm reduction efforts or for individuals with levels of severity that do not require abstinence as a treatment goal.

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Drugs for Relapse Prevention of Alcoholism, 2005 by Rainer Spanagel, Karl F. Mann


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