By Edward J. Massaro
Within the instruction manual of Neurotoxicology, Volumes I and II, many top researchers and clinicians-all stated experts-review extensive the prestige of study in key components of present neurotoxicologic curiosity and consider the newest methodologies for in vivo review of a large spectrum of brokers displaying neurotoxicologic houses. the 1st quantity of the guide specializes in the organic results of human-made neurotoxins, in addition to these of traditional starting place, which so frequently supply beneficial therapeutics and examine reagents. issues variety from anticholinesterase pesticides and insecticides that focus on ion channels, to such metals as mercury, lead, zinc, and to the polytypic byproducts of combustion and business manufacture. The traditional pollutants mentioned comprise these of microbial starting place (microbial, marine, clostridial, and botulilinal neurotoxins), in addition to these of animal beginning (snake, spider, and scorpion venoms). the second one quantity concentrates at the organic results of human-made pollution at the constructing worried approach, stories the neuronal influence of gear of abuse, and gives state of the art tools for the overview of the organic results of neurotoxicants by means of either imaging and neurobehavioral review.
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Extra resources for Handbook of Neurotoxicology, Volume 1
J. (1994a) Organophosphorus ester insecticides, in Pesticides and Neurological Diseases, 2nd ed. (Ecobichon, D. J. and Joy, R. ), CRC, Boca Raton, FL, pp. 171–249. 14. Neal, R. A. , and Philpot, R. ), Elsevier North Holland, New York, NY, pp. 131–171. 15. Chambers, J. , Boone, J. , and Chambers, H. W. (1994) Role of detoxication pathways in acute toxicity levels of phosphorothionate insecticides in the rat. Life Sci. 54, 1357–1364. 16. Chambers, J. E. and Chambers, H. W. (1991) Biotransformation of organophosphorus insecticides in mammals, in Pesticide Transformation Products Fate and Significance in the Environment (Somasundaram, L.
And Ho, I. K. (1992) Tolerance to organophosphorus cholinesterase inhibitors, in Organophosphates: Chemistry, Fate, and Effects (Chambers, J. , Levi, P. ), Academic Press, San Diego, CA, pp. 285–297. 26. Eldefrawi, A. , and Eldefrawi, M. E. E. ), Academic Press, San Diego, CA, pp. 258–270. OPIDN 17 2 Organophosphate-Induced Delayed Neuropathy Marion Ehrich and Bernard S. Jortner 1. INTRODUCTION/HISTORY Although the cholinesterase-inhibiting effects of organophosphate (OP) compounds were not utilized until the time of World War II, the ability of some of these chemicals to cause an irreversible, progressive delayed neuropathy was recognized as early as the 1890s, when a 15% solution of tri-ortho-cresyl phosphate (TOCP, or tri-ortho-tolyl phosphate, TOTP) was used to treat tuberculosis.
And Richardson, R. J. (1980) Organophosphorus compounds, in Experimental and Clinical Neurotoxicology (Spencer, P. S. and Schaumburg, H. ), Williams & Wilkins, Baltimore, pp. 527–544. 4. Ecobichon, D. J. (1994) Organophosphorus insecticides, in Pesticides and Neurological Diseases (Ecobichon, D. J. and Joy, R. ), CRC Press, Boca Raton, FL, pp. 171–249. 5. Johnson, M. K. (1982) The target for initiation of delayed neurotoxicity by organophosphorus esters: biochemical studies and toxicological applications, in Reviews in Biochemical Toxicology, vol.
Handbook of Neurotoxicology, Volume 1 by Edward J. Massaro