By Mariusz Skwarczynski, Istvan Toth

ISBN-10: 0323399819

ISBN-13: 9780323399814

ISBN-10: 0323400299

ISBN-13: 9780323400299

This booklet presents a accomplished review of the way use of micro- and nanotechnology (MNT) has allowed significant new boost in vaccine improvement examine, and the demanding situations that immunologists face in making additional progress.

MNT permits the construction of debris that take advantage of the inherent skill of the human immune process to acknowledge small debris comparable to viruses and pollution. together with minimum protecting epitope layout, this allows the construction of immunogenic debris that stimulate a reaction opposed to the distinct pathogen. The finely tuned reaction of the human immune method to small debris makes it unsurprising that the various lead adjuvants and vaccine supply structures presently lower than research are in keeping with nanoparticles.

  • Provides a entire and unheard of review of the position of micro- and nanotechnology in vaccine development
  • Allows researchers to speedy familiarize themselves with the extensive spectrum of vaccines and the way micro- and nanotechnologies are utilized to their development
  • Includes a mixture of assessment chapters starting off common rules, and concentrated content material facing particular vaccines, making it beneficial to readers from various disciplines

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Extra resources for Micro and Nanotechnology in Vaccine Development

Sample text

P. Davis and M. 6 Examples of nanoparticle drug delivery systems and surface modifications. 120). 125,126 However, it is challenging to separate these effects from carrier composition, as often the change of a single nanoparticle property is not possible without a resulting alteration of other parameters. 7 Formation of five morphologies from a single polymer under different assembly conditions. From left counterclockwise: (A) spheres, (B) vesicles, (C) worm-like nanoparticles, (D) flower-like nanoparticles, (D) large compound nanoparticles.

51. Phillips WT, Goins BA, Bao A. Radioactive liposomes. WIREs Nanomed Nanbiotechnol 2009;1(1): 69–83. 52. Almutairi A, Rossin R, Shokeen M, Hagooly A, Ananth A, Capoccia B, Guillaudeu S, Abendschein D, Anderson CJ, Welch MJ, Fréchet JMJ. Biodegradable dendritic positron-emitting nanoprobes for the noninvasive imaging of angiogenesis. PNAS 2009;106(3):685–90. 53. Sun X, Cai W, Chen X. Positron emission tomography imaging using radiolabeled inorganic nanomaterials. Acc Chem Res 2015;48(2):286–94.

65. Vivero-Escoto JL, Huxford-Phillips RC, Lin W. Silica-based nanoprobes for biomedical imaging and theranostic applications. Chem Soc Rev 2012;41(7):2673–85. 66. Benezra M, Penate-Medina O, Zanzonico PB, Schaer D, Ow H, Burns A, DeStanchina E, Longo V, Herz E, Iyer S, Wolchok J, Larson SM, Wiesner U, Bradbury MS. Multimodal silica nanoparticles are effective cancer-targeted probes in a model of human melanoma. J Clin Invest 2011;121(7):2768–80. 67. Lee J-J, White AG, Rice DR, Smith BD. In vivo imaging using polymeric nanoparticles stained with near-infrared chemiluminescent and fluorescent squaraine catenane endoperoxide.

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Micro and Nanotechnology in Vaccine Development by Mariusz Skwarczynski, Istvan Toth


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