By Paul Flecknell, Avril Waterman-Pearson BVSc PhD FRCVS DVA DiplECVA

ISBN-10: 0702017671

ISBN-13: 9780702017674

Finally a very sturdy functional e-book on the right way to deal with ache. It basically summarises the proof that animals think discomfort after which - this the simplest bit - turns the technological know-how into actual aid for front-line working towards vets.

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Example text

Carprofen is an exc eption to the general rule to avoid using NSAIDs before or during anaesthesia or in animal s with compromised ren al blood flow, due to its weak inhibition of COX isocnzymes. It has a licence for preoperative use. ]8 PHARMACOLOGY OF ANALGESIC DRUGS Chapter 3 Meclofenamic acid has been reported to prolong the gestation period of some species, presumably because of the involvement of prostaglandins in uterine contraction at parturition. It is advisable not to use NSAIDs at this time.

However, legally these drugs cannot be used in food producing animals unless a guarantee can be provided that the animals in question will not enter the food chain. Non-steroidal antiinflammatory drugs Pharmacological properties The non-steroidal antiinflammatory drugs (NSAIDs) are a group of weak organic acids, carboxylic acids (aspirin, cincophen, carprofen, flunixin) and the enolic acids (phenylbutazone, meloxicam), with antiinflammatory, analgesic (peripheral and central sites of action) and antipyretic properties (central site of 35 Chapter 3 action).

Morphine, like all the opioids, is not licensed for use in animals intended for human consumption. It appears to be analgesic in cattle and pigs, but the duration of action is probably considerably less than 4 h due to more rapid metabolism. For dosing information see chapter 5. When given by oral or rectal routes, the bioavailability of morphine in dogs is low (Barnhart et al 2000). Papaveretum is a crude form of morphine licensed in humans as a combination product along with other alkaloids. Its actions are very similar to those of morphine.

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Pain Management in Animals by Paul Flecknell, Avril Waterman-Pearson BVSc PhD FRCVS DVA DiplECVA

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