By ILO;UNEP

ISBN-10: 9241572361

ISBN-13: 9789241572361

This new quantity within the Environmental well-being standards sequence presents a framework for the evaluate of the position of chemical hazard components within the improvement of autoimmune illnesses. as well as a basic advent to autoimmune mechanisms and medical expression of autoimmune ailments, a dialogue of mechanisms of chemical-associated autoimmune responses precedes details on a number of chemical and different brokers. Animal versions and human trying out for autoimmune disorder and the appliance of knowledge in possibility evaluation are provided. This ebook could be beneficial to biology and toxicology scientists and researchers, in addition to to regulatory specialists, undefined, and the final probability review group.

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Additional resources for Principles and Methods for Assessing Autoimmunity Associated with Exposure to Chemicals: Environmental Health Criteria Series No. 236 (Environmental Health Criteria)

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Inflammation is a stereotypic defensive response of the body to most forms of tissue injury, whether chemical, physical, or infectious. The cardinal signs of redness, pain, heat, and swelling serve to localize the infection and recruit cells of the innate immune response. They include the major circulating phagocytic cells, neutrophils, which leave the blood and migrate to inflamed areas. The process involves, first, adherence of the cells to the vascular endothelium of vessels near the damaged tissue site, followed by passage through the endothelial lining and chemotactic attraction to the site of damage.

4 Mechanisms of self-tolerance To carry out its function of recognizing the universe of possible molecules, the immune system generates a great diversity of receptors. Inevitably, some of these receptors will react with antigens present in the body of the host itself. Recognition of autoantigens may result in harm to the host, referred to as autoimmune disease. It is important for survival that these self-directed reactions be avoided or limited so that harm does not follow, the phenomenon called selftolerance.

The amplification mechanisms include epitope spread, which involves the recruitment of additional antigenic determinants on the self-reactive antigen molecule. We distinguish this intramolecular epitope spreading from immune escalation, which describes the extension of the autoimmune response to other antigenic molecules in the same target organ. It is characteristic of almost all of the autoimmune diseases that multiple autoantibodies are produced after the disease is under way, probably reflecting an adjuvant effect.

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Principles and Methods for Assessing Autoimmunity Associated with Exposure to Chemicals: Environmental Health Criteria Series No. 236 (Environmental Health Criteria) by ILO;UNEP


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