By Sherif S. Ebada, Neil Lajkiewicz (auth.), A. Douglas Kinghorn, Heinz Falk, Junichi Kobayashi (eds.)

ISBN-10: 3709107474

ISBN-13: 9783709107478

ISBN-10: 3709107482

ISBN-13: 9783709107485

The 3 reports conceal the advances within the chemistry and biology of withanolides during the last sixteen years, evaluate the chemistry and biology of the rocaglamide-type derivatives and similar compounds, with emphasis on their structural range, biosynthesis, pharmacological importance and overall synthesis, and summarize the large chemistry and biology reports on a ordinary product, that have led to a unique remedy authorized around the globe.

Show description

Read or Download Progress in the Chemistry of Organic Natural Products Vol. 94 PDF

Best chemistry books

Get Advances in Nitrogen Heterocycles, Volume 3 PDF

This quantity encompasses a diversity of issues resembling the activation and manipulation of pyrroles, the synthesis of annelated pyrroles utilizing acylation reactions and the synthesis of kainoids, a relations of hugely biologically lively nitrogen heterocycles.

Download e-book for kindle: Applied Polymer Science<span class="edition", Second by Roy W. Tess and Gary W. Poehlein (Eds.)

Content material: A century of polymer technology and know-how / Herman F. Mark -- advent to polymer technological know-how and expertise / Charles E. Carraher, Jr. and Raymond B. Seymour -- Anionic polymerization / Maurice Morton -- Coordinated anionic polymerization and polymerization mechanisms / Frederick J. Karol -- contemporary advancements in cationic polymerization / Virgil Percec -- Emulsion polymerization / Gary W.

Additional info for Progress in the Chemistry of Organic Natural Products Vol. 94

Sample text

In the studies with S. littoralis, different rocaglamide derivatives were usually added at a range of concentrations to artificial diet, which was subsequently offered to newly hatched larvae in a no choice chronic feeding bioassay. S. Ebada et al. Fig. 11. Chemical structure of azadirachtin from Azadirachta indica (family Meliaceae) O O O COOCH3 OH O O H3COCO H3COOC O OH OH O the various rocaglamide congeners and compared to other insecticides of natural origin, such as azadirachtin from Azadirachta indica (family Meliaceae) (Fig.

G. the human acute T cell leukemia Jurkat, the human T cell lymphoma Hut78, the EBV-transformed human B lymphoblast SKW, and also primary tumor cells freshly isolated from patients having acute myeloid (AML), acute lymphoblastic (ALL), and chronic myeloid (CML) leukemias. Interestingly, rocaglamide (1) showed no or very low toxicities to normal peripheral blood T and B lymphocytes and had also very little toxicity to human bone marrow stem cells (100). Investigation of the molecular mechanisms by which rocaglamide (1) and 1-O-acetylrocaglamide (4) killed tumors but not normal cells revealed that these compounds preferentially induce apoptosis in malignant cells by differential modulation of the activities of ERK, p38, and JNK.

According to this hypothesis, the initial C-C-connecting step (step A) between C-2 of the flavonoid I and C-3 of the cinnamic acid amide II is a Michael-type 1,4-addition of the enolate subunit of I to the a,b-unsaturated amide II. The C-2 atom of the resulting amide enolate of III can now attack C-4 of the previous flavonoid, which has now become a strongly activated carbonyl group, to yield a five-membered ring, giving rise to IV (step B). According to this concept, IV constitutes the biosynthetic key intermediate and precursor both to aglain and rocaglamide derivatives.

Download PDF sample

Progress in the Chemistry of Organic Natural Products Vol. 94 by Sherif S. Ebada, Neil Lajkiewicz (auth.), A. Douglas Kinghorn, Heinz Falk, Junichi Kobayashi (eds.)

by Jeff

Rated 4.86 of 5 – based on 9 votes