By Gary W Miller

ISBN-10: 0124172172

ISBN-13: 9780124172173

The Exposome: A Primer is the 1st publication devoted to exposomics, detailing the aim and scope of this rising box of research, its sensible purposes and the way it enhances a huge variety of disciplines. Genetic explanations account for as much as a 3rd of all complicated illnesses. (As genomic techniques enhance, this is often prone to rise.) Environmental components additionally impression human disorder yet, in contrast to with genetics, there's no commonplace or systematic technique to degree the effect of environmental exposures. The exposome is an rising idea that hopes to handle this, measuring the results of life-long environmental exposures on health and wellbeing and the way those exposures can impact illness.

This systematic advent considers issues of handling and integrating exposome facts (including maps, versions, computation, and platforms biology), "-omics"-based applied sciences, and extra. either scholars and scientists in disciplines together with toxicology, environmental health and wellbeing, epidemiology, and public healthiness will make the most of this rigorous but readable overview.

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If findings from toxicology studies make their way into the exposome construct, which they should, then by its very nature the research will be translational as it is being incorporated into a model aimed at improving human health. 3 EXPOSURE SCIENCE (OR ASSESSMENT, OR BIOLOGY) For decades, the field of exposure assessment has been determining the composition of our surroundings and how various contaminants enter the body. More recently, the term exposure biology has been used to describe the study of the biological aspects of exposures and is one that biomedical funding agencies seem to prefer in that it is more aligned with their biologically-based approaches.

Unfortunately, this toxicological catchphrase is unable to capture the nuances and shape of the curve. Decades ago the relationships were thought to be not far from linear. Paracelsus taught us that good things can be bad at high doses, so the thought that bad things can be good at low doses seems counterintuitive. But in fact there is strong evidence to support the concept of hormesis for many classes of compounds and some biological pathways. Hormesis is the term used to describe the phenomenon where low doses of a compound, which is demonstrably toxic at higher doses, may actually provide a beneficial effect.

A structure for deoxyribose nucleic acid. Nature 1953;171:737À8. Watson JD, Crick FHC. Genetic implications of the structure of deoxyribonucleic acid. Nature 1953;171:964À7 (The follow up paper that proposed the copying mechanism of DNA) Wilkins MHF, Stokes AR, Wilson HR. Molecular structure of deoxypentose nucleic acids. Nature 1953;171:738À40. ). A quick PubMed search for the various -omes and -omic technologies reveals a breadth of acceptance and utility. The genome is obviously the most commonly used -ome and was coined nearly a century ago.

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The Exposome. A Primer by Gary W Miller

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