By John P. Griffin

ISBN-10: 1405180358

ISBN-13: 9781405180351

The Textbook of Pharmaceutical medication is a regular reference for all these operating in pharmaceutical drugs and the known textual content for the united kingdom school of Pharmaceutical medication degree. this can be a accomplished quantity masking the approaches wherein medications are constructed, verified and authorized. laws for drug improvement within the united kingdom, ecu, united states, Australia and Japan are mentioned, supplying suitable info for drug approval mostly continents the place new medications are developed.The chapters are written through top teachers, scientific administrators and legal professionals, delivering authoritative and in-depth info for trainees at the school path, and for physicians operating within the pharmaceutical undefined. in addition to thorough updating of the regulatory chapters, the sixth edition includes chapters on those important new areas:Paediatric regulationEthicsDue diligence and the pharmaceutical health care professional

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Extra info for The Textbook of Pharmaceutical Medicine, Sixth Edition

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98 It should be emphasised, however, that characterisation of a different protein in a disease state does not necessarily means that it has a causal role or represents a potential therapeutic target. In many cases, the new protein may be a consequence of the disease rather than the cause. Further studies are required to check whether the activity of a candidate target eliminated by molecular/cellular techniques could reverse the disease phenotype. Moreover, even when a potential therapeutic target has been identified and a molecule capable of disrupting it has been obtained, we cannot assume it will constitute an effective treatment for the disease under investigation.

Thus, completion of the human genome will not provide an immediate solution to the genetics of complex diseases. qxd 8/21/09 9:24 Page 17 Discovery of new medicines 17 genomes at the population level within and across ethnic groups and by characterising mutant genes. DNA microarray analysis is an important technique which is used as a means to probe the expression of thousands of genes simultaneously and to study a wide range of biologic processes. 71 For further progress it is essential to identify the function of each gene in the normal and disease situation and establish a link with the expressed protein (before and after post-translational modification) and its role in physiological and disease pathways.

Which cellular pathways or complexes the protein participates in), rather than by suggesting a specific biochemical activity. 104 Comprehensive sets of purified peptides and proteins permit high-throughput screening for discrete biochemical properties, whereas formats involving living cells facilitate large-scale genetic screening for novel biological activities. Protein arrays can be engineered to suit the aims of a particular experiment. Thus, an array might contain all the combinatorial variants of a bioactive peptide or specific variants of a single protein species (splice variants, domains or mutants), a family of protein orthologs from different species, a protein pathway or even the entire protein complement of an organism.

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The Textbook of Pharmaceutical Medicine, Sixth Edition by John P. Griffin

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