By Saura C. Sahu
Epigenetics is the examine of either heritable and non-heritable adjustments within the legislation of gene job and expression that ensue with no an alteration within the DNA sequence. This dynamic and speedily constructing self-discipline is making its impression around the biomedical sciences, particularly in toxicology the place epigenetic alterations can suggest that various contributors reply in a different way to a similar drug or chemical.
Toxicology and Epigenetics displays the multidimensional personality of this rising zone of toxicology, describing state of the art molecular applied sciences to solve epigenetic adjustments, using in vivo and in vitro models, in addition to the aptitude use of toxicological epigenetics in regulatory environments. a world group of specialists give some thought to the interaction among epigenetics and toxicology in a couple of components, together with environmental, dietary, pharmacological, and computational toxicology, nanomaterials, proteomics and metabolomics, and melanoma research.
Topics lined include:
- environment, epigenetics and diseases
- DNA methylation and toxicogenomics
- chromatin on the intersection of ailment and therapy
- epigenomic activities of environmental arsenicals
- environment, epigenetics and cardiovascular health
- toxicology, epigenetics and autoimmunity
- ocular epigenomics: power websites of environmental influence in improvement and disease
- nuclear RNA silencing and comparable phenomena in animals
- epigenomics – effect for drug safeguard sciences
- methods of worldwide epigenomic profiling
- transcriptomics: purposes in epigenetic toxicology
Toxicology and Epigenetics is a vital perception into the present tendencies and destiny instructions of analysis during this swiftly increasing box for investigators, toxicologists, hazard assessors and regulators in academia, and government.
Chapter 1 creation (pages 1–3): Saura C. Sahu
Chapter 2 surroundings, Epigenetics, and ailments (pages 5–24): Robert Y. S. Cheng and Wan?yee Tang
Chapter three DNA Methylation and Toxicogenomics (pages 25–50): Deepti Deobagkar
Chapter four Chromatin on the Intersection of ailment and treatment (pages 51–71): Delphine Quenet, Marcin Walkiewicz and Yamini Dalal
Chapter five Molecular Epigenetic adjustments brought on by Environmental toxins (pages 73–109): Solange S. Lewis, Gregory J. Weber, Jennifer L. Freeman and Maria S. Sepulveda
Chapter 6 Epigenetic Mediation of Environmental Exposures to Polycyclic fragrant Hydrocarbons (pages 111–127): Bekim Sadikovic and David I. Rodenhiser
Chapter 7 Epigenomic activities of Environmental Arsenicals (pages 129–148): Paul L. Severson and Bernard W. Futscher
Chapter eight Arsenic?Induced alterations to the Epigenome (pages 149–190): Kathryn A. Bailey and Rebecca C. Fry
Chapter nine Environmental Epigenetics, bronchial asthma, and hypersensitivity: Our Environment's Molecular Footprints (pages 191–203): Stephanie Lovinsky?Desir and Rachel L. Miller
Chapter 10 miRNAs in Human Prostate melanoma (pages 205–217): Ernest ok. Amankwah and Jong Y. Park
Chapter eleven setting, Epigenetics, and Cardiovascular future health (pages 219–239): Sanjukta Ghosh and Andrea Baccarelli
Chapter 12 Toxicology, Epigenetics, and Autoimmunity (pages 241–260): Craig A. Cooney and Kathleen M. Gilbert
Chapter thirteen Toxicoepigenomics in Lupus (pages 261–274): Donna Ray and Bruce C. Richardson
Chapter 14 Ocular Epigenomics: strength websites of Environmental influence in improvement and sickness (pages 275–295): Kenneth P. Mitton
Chapter 15 Nuclear RNA Silencing and comparable Phenomena in Animals (pages 297–315): Radek Malik and Petr Svoboda
Chapter sixteen Epigenetic Biomarkers in melanoma Detection and prognosis (pages 317–338): Ashley G. Rivenbark and William B. Coleman
Chapter 17 Epigenetic Histone adjustments within the Toxicologic Mode of motion of Arsenic (pages 339–356): John F. Reichard and Alvaro Puga
Chapter 18 Irreversible results of Diethylstilbestrol on Reproductive Organs and a present method for Epigenetic results of Endocrine Disrupting chemical compounds (pages 357–364): Shinichi Miyagawa, Ryohei Yatsu, Tamotsu Sudo, Katsuhide Igarashi, Jun Kanno and Taisen Iguchi
Chapter 19 Epigenomics – effect for Drug safeguard Sciences (pages 365–385): Harri Lempiainen, Raphaelle Luisier, Arne Muller, Philippe Marc, David Heard, Federico Bolognani, Pierre Moulin, Philippe Couttet, Olivier Grenet, Jennifer Marlowe, Jonathan Moggs and Remi Terranova
Chapter 20 Archival Toxicoepigenetics: Molecular research of changed DNA from Preserved Tissues in Toxicology experiences (pages 387–407): B. Alex Merrick
Chapter 21 Nanoparticles and Toxicoepigenomics (pages 409–426): Manasi P. Jain, Angela O. Choi and Dusica Maysinger
Chapter 22 tools of worldwide Epigenomic Profiling (pages 427–443): Michael W. Y. Chan, Zhengang Peng, Jennifer Chao Weber, Ying?Wei Li, Matthew T. Zuzolo and Huey?Jen L. Lin
Chapter 23 Transcriptomics: purposes in Epigenetic Toxicology (pages 445–458): Pius Joseph
Chapter 24 Carcinogenic Metals regulate Histone Tail changes (pages 459–474): Yana Chervona and Max Costa
Chapter 25 Prediction of Epigenetic and Stochastic Gene Expression Profiles of past due results after Radiation publicity (pages 475–510): Yoko Hirabayashi and Tohru Inoue
Chapter 26 Modulation of Developmentally Regulated Gene Expression courses via focusing on of Polycomb and Trithorax team Proteins (pages 511–538): Marjorie model and F. J. Dilworth
Chapter 27 Chromatin Insulators and Epigenetic Inheritance in well-being and illness (pages 539–567): Jingping Yang and Victor G. Corces
Chapter 28 Bioinformatics for High?Throughput Toxico?Epigenomics reports (pages 569–588): Maureen A. Sartor, Dana C. Dolinoy, Laura S. Rozek and Gilbert S. Omenn
Chapter 29 Computational tools in Toxicoepigenomics (pages 589–593): Joo Chuan Tong
Chapter 30 Databases and instruments for Computational Epigenomics (pages 595–614): V. Umashankar and S. Gurunathan
Chapter 31 Interface of Epigenetics and Carcinogenic hazard review (pages 615–630): Paul Nioi
Chapter 32 Epigenetic alterations in Chemical Carcinogenesis (pages 631–643): Igor P. Pogribny, Igor Koturbash and Frederick A. Beland
Chapter 33 program of melanoma Toxicoepigenomics in making a choice on High?Risk Populations (pages 645–652): Mukesh Verma and Krishna ok. Banaudha
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Extra resources for Toxicology and Epigenetics
Mol. , 24 (5), 993–1006. H. et al. (2000) Nickel compounds are novel inhibitors of histone H4 acetylation. , 60 (2), 238–241. L. G. (2011) Developmental exposure to TCDD reduces fertility and negatively affects pregnancy outcomes across multiple generations. Reprod. , 31 (3), 344–350. Bushati, N. M. (2007) microRNA functions. Annu. Rev. Cell Dev. , 23, 175–205. F. (2009) The role of epigenetics in aging and age-related diseases. Ageing Res. , 8 (4), 268–276. , Salnikow, K. et al. (2002) Molecular mechanisms of nickel carcinogenesis.
Et al. (2002) Molecular mechanisms of nickel carcinogenesis. Toxicol. , 127 (1–3), 69–75. A. O. (2003) Transcriptional control of the DNA methyltransferases is altered in aging and neoplastically-transformed human ﬁbroblasts. Mol. Cell. , 252 (1–2), 33–43. A. et al. (2003) Increased homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease. Clin. , 49 (8), 1292–1296. , Guhamazumder, D. et al. (2006) DNA hypermethylation of promoter of gene p53 and p16 in arsenic-exposed people with and without malignancy.
Maternal exposure to BPA in rat was shown to modify methylation of the metastable loci, the viable yellow agouti (Avy), and CDK5 activator-binding protein (CabpIAP). Interestingly, this effect on DNA methylation and the associated change in coat color of the exposed animals were prevented by a maternal dietary supplementation with folic acid or genistein (Dolinoy, Huang, and Jirtle, 2007a). On the other hand, neonatal exposure to BPA in rat was found to induce adverse effects in spermatogenesis and fertility and aberrant DNA methylation in the testis (Salian, Doshi, and Vanage, 2009).
Toxicology and Epigenetics by Saura C. Sahu