By Shih-Houng Young Ph.D., Vincent Castranova

ISBN-10: 041570037X

ISBN-13: 9780415700375

The research of indoor air caliber has proven that microbial illness is usually a challenge in structures. contemporary facts exhibits that fungi are frequently part of the image. an element of the fungal mobilephone wall, 1®3-?-glucans not just have an effect on human future health, they're a marker for the lifestyles of fungi in environmental samples. Toxicology of 1®3-?-Glucans covers the fundamental chemistry and immunobiology of those components. The authors commence by means of introducing present tools for detecting 1®3-?-glucans in environmental samples and reviewing probability overview within the surroundings. They pass directly to speak about various subject matters together with most likely occupational and environmental publicity, stories suggesting a robust hyperlink among environmental glucan concentrations and pulmonary irritation, and sign transduction pathways and particular receptors. No different publication presently on hand brings jointly the services of major foreign researchers to supply a simple monograph at the toxicology of 1®3-?-glucans. It pulls jointly present wisdom of those compounds, their results, dimension, tracking, and hazard evaluation.

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Extra resources for Toxicology of 1 - 3-Beta-Glucans: Glucans as a Marker for Fungal Exposure

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1992). Airborne beta-1,3glucan may be related to symptoms in sick buildings. Indoor Environ. 1, 263–267. , and Sasaki, T. (1977). A 13C nuclear magnetic resonance study of gelforming (1-3)-beta-D-glucans. Evidence of the presence of single-helical conformation in a resilient gel of a curdlan-type polysaccharide 13140 from alcaligenes faecalis var. myxogenes IFO 13140. Biochem. 16, 908–914. , and Uehara, N. (1991). Relationship between conformation and biological response for (1-3)-β-D-glucan in the activation of coagulation Factor G from Limulus amebocyte lysate and host-mediated antitumor activity.

R. (2003). Partially opened triple helix is the biologically active conformation of 13beta-glucans that induces pulmonary inflammation in rats. J. Toxicol. Environ. Health Part A 66, 551–563. , Walker, G. , and Fesik, S. W. (1993). Heteronuclear NMR studies of 13C-labeled yeast cell wall β-glucan oligosaccharides. J. Biomol. NMR 3, 429–441. Zimmerman, J. , Fish, P. , Palace, G. , Stevenson, T. , and DeMong, D. E. (1998). A novel carbohydrate-glycosphingolipid interaction between a beta-(13)-glucan immunomodulator, PGG-glucan, and lactosylceramide of human leukocytes.

Adams, D. , Pero, S. , and Wakshull, E. (2000). Activation of a Rel-A/CEBP-beta-related transcription factor heteromer by PGG-glucan in a murine monocytic cell line. J. Cell Biochem. 77, 221–233. 28 Toxicology of 1→3-β-Glucans Ahren, I. , Williams, D. , Rice, P. , and Riesbeck, K. (2001). The importance of a beta-glucan receptor in the nonopsonic entry of nontypeable Haemophilus influenzae into human monocytic and epithelial cells. J. Infect. Dis. 184, 150–158. Ahren, I. , and Riesbeck, K. (2003).

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Toxicology of 1 - 3-Beta-Glucans: Glucans as a Marker for Fungal Exposure by Shih-Houng Young Ph.D., Vincent Castranova


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