By Shih-Houng Young Ph.D., Vincent Castranova
The research of indoor air caliber has proven that microbial illness is usually a challenge in structures. contemporary facts exhibits that fungi are frequently part of the image. an element of the fungal mobilephone wall, 1®3-?-glucans not just have an effect on human future health, they're a marker for the lifestyles of fungi in environmental samples. Toxicology of 1®3-?-Glucans covers the fundamental chemistry and immunobiology of those components. The authors commence by means of introducing present tools for detecting 1®3-?-glucans in environmental samples and reviewing probability overview within the surroundings. They pass directly to speak about various subject matters together with most likely occupational and environmental publicity, stories suggesting a robust hyperlink among environmental glucan concentrations and pulmonary irritation, and sign transduction pathways and particular receptors. No different publication presently on hand brings jointly the services of major foreign researchers to supply a simple monograph at the toxicology of 1®3-?-glucans. It pulls jointly present wisdom of those compounds, their results, dimension, tracking, and hazard evaluation.
Read Online or Download Toxicology of 1 - 3-Beta-Glucans: Glucans as a Marker for Fungal Exposure PDF
Best toxicology books
Addressing the various gaps in present info, objective Organ Toxicology in Marine and Freshwater Teleosts is a vital source for researchers and execs in aquatic toxicology and environmental threat overview. the entire chapters are written through researchers who're the world over recognized for his or her paintings in mechanistic features of aquatic toxicology. each one bankruptcy makes a speciality of a selected goal organ or physiological procedure and describes how a number of brokers disrupt the traditional physiological method and techniques. This quantity is dedicated to precise organs with insurance of the gill, kidney, pores and skin, liver and intestine. The spouse quantity, platforms, presents assurance of poisonous results within the relevant worried, immune, neurobehavioural and reproductive platforms in addition to describing common mechanisms of toxicity.
This e-book offers with the equipment and medical foundation of inhalation toxicology. It describes units and amenities had to divulge animals to inhaled debris and gases in addition to techniques to estimating or measuring the fraction of the inhaled fabric that's retained within the breathing tract. The booklet then studies the evergrowing repertoire of ideas that may be used to degree the responses elicited through the publicity.
Hair research in medical and Forensic Toxicology is a necessary reference for toxicologists operating with, and gaining knowledge of, hair research. The textual content provides a assessment of the main updated analytical tools in toxicological hair research, besides cutting-edge advancements within the components of hair body structure, sampling, and pre-treatments, in addition to discussions of primary concerns, functions, and effects interpretation.
- Hamilton and Hardy's Industrial Toxicology
- Behavioral Toxicology
- Toxicology - From Cells to Man: Proceedings of the 1995 EUROTOX Congress Meeting Held in Prague, Czech Republic, August 27–l30, 1995
- Principles of Biochemical Toxicology, Fourth Edition
Extra resources for Toxicology of 1 - 3-Beta-Glucans: Glucans as a Marker for Fungal Exposure
1992). Airborne beta-1,3glucan may be related to symptoms in sick buildings. Indoor Environ. 1, 263–267. , and Sasaki, T. (1977). A 13C nuclear magnetic resonance study of gelforming (1-3)-beta-D-glucans. Evidence of the presence of single-helical conformation in a resilient gel of a curdlan-type polysaccharide 13140 from alcaligenes faecalis var. myxogenes IFO 13140. Biochem. 16, 908–914. , and Uehara, N. (1991). Relationship between conformation and biological response for (1-3)-β-D-glucan in the activation of coagulation Factor G from Limulus amebocyte lysate and host-mediated antitumor activity.
R. (2003). Partially opened triple helix is the biologically active conformation of 13beta-glucans that induces pulmonary inflammation in rats. J. Toxicol. Environ. Health Part A 66, 551–563. , Walker, G. , and Fesik, S. W. (1993). Heteronuclear NMR studies of 13C-labeled yeast cell wall β-glucan oligosaccharides. J. Biomol. NMR 3, 429–441. Zimmerman, J. , Fish, P. , Palace, G. , Stevenson, T. , and DeMong, D. E. (1998). A novel carbohydrate-glycosphingolipid interaction between a beta-(13)-glucan immunomodulator, PGG-glucan, and lactosylceramide of human leukocytes.
Adams, D. , Pero, S. , and Wakshull, E. (2000). Activation of a Rel-A/CEBP-beta-related transcription factor heteromer by PGG-glucan in a murine monocytic cell line. J. Cell Biochem. 77, 221–233. 28 Toxicology of 1→3-β-Glucans Ahren, I. , Williams, D. , Rice, P. , and Riesbeck, K. (2001). The importance of a beta-glucan receptor in the nonopsonic entry of nontypeable Haemophilus influenzae into human monocytic and epithelial cells. J. Infect. Dis. 184, 150–158. Ahren, I. , and Riesbeck, K. (2003).
Toxicology of 1 - 3-Beta-Glucans: Glucans as a Marker for Fungal Exposure by Shih-Houng Young Ph.D., Vincent Castranova