By Yogesh C. Awasthi
Crucial enzymes preserving human and different organisms from most likely poisonous chemical substances, Glutathione S-transferases (GSTs) are imperative to uncomplicated mechanisms akin to pressure reaction and physiological capabilities together with safety opposed to lipid peroxidation. This booklet describes the position of GST in toxicology, targeting their pharmacologic and physiological roles and their relevance to organic toxicology. It covers constitution and serve as, gene legislation, and those enzymes’ involvement in sign transduction. Reflecting present tendencies during this increasing study sector, Toxicology of Glutathione Transferases is the single resource that info the tools of GST examine.
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Additional resources for Toxicology of Glutathione Transferases
Fm Page 26 Friday, May 26, 2006 3:08 PM 26 Toxicology of Glutathione Transferases 92. Lumjuan, N. , Elevated activity of an Epsilon class glutathione transferase confers DDT resistance in the dengue vector, Aedes aegypti, Insect Biochem. Mol. Biol. 35, 861, 2005. 93. Zou, S. , Genome-wide study of aging and oxidative stress response in Drosophila melanogaster, Proc. Natl. Acad. Sci. USA 97, 13726, 2000. 94. C. , Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis, Hum.
87 Many insect GSTs, such as the first member of the Epsilon class87 or the Delta-class enzyme from Lucilia cuprina,88 were initially classified as Theta. We characterized the Epsilon GST as well as ten members of the Delta cluster by heterologous expression in E. 80 Analysis of genome sequences of D. melanogaster89 and of other insects such as Anopheles gambiae4 led to the identification of further genes of these classes. Currently, 11 Delta-class and 14 Epsilon-class genes are known to exist in D.
279, 4027, 2004. 87. Singh, M. , Cloning and characterization of a new theta-class glutathione-Stransferase (GST) gene, gst-3, from Drosophila melanogaster, Gene 247, 167, 2000. 88. J. , Crystal structure of a theta-class glutathione transferase, Embo. J. 14, 2133, 1995. 89. D. , The genome sequence of Drosophila melanogaster, Science 287, 2185, 2000. 90. J. , The crystal structures of glutathione S-transferases isozymes 1–3 and 1–4 from Anopheles dirus species B, Protein Sci. 10 (11), 2176, 2001.
Toxicology of Glutathione Transferases by Yogesh C. Awasthi