By S. Miyagawa

ISBN-10: 9533079975

ISBN-13: 9789533079974

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Com. Endocrinol. 148, 2, pp. (125-131) Al-Jazaeri A, Xu B-Y, Yang H, MacNeil D, Leventhal JR, & Wright JR Jr. (2005). Effect of glucose toxicity on intraportal tilapia islet xenotransplantation in nude mice. Xenotransplantation 12, pp. (189-196) Coddington DA, Lawen JG, Yang H, O'Hali W, & Wright JR Jr. (1997). Xenotransplantation of fish islets into the non-cryptorchid testis. Transplant. Proc. 29, pp. (2083-2085) Conlon JM & Larhammar D. (2005). The evolution of neuroendocrine peptides. Gen. Comp.

Therefore, we decided to make and patent transgenic tilapia expressing a “humanized” tilapia insulin gene (Wright & Pohajdak, 2000; Wright & Pohajdak, 2002). This was accomplished by cloning and sequencing the tilapia insulin gene (Mansour et al. , 2004). Resulting offspring were simultaneously screened by PCR using tilapia insulin gene-specific primers and humanized tilapia insulin gene-specific primers. , 2008), demonstrated germ-line expression and passed the transgene on to some of his offspring.

2004). This advantage could greatly facilitate the widespread implementation of clinical islet xenotransplantation as a cure for type I diabetes. Piscine Islet Xenotransplantation 31 5. Acknowledgment Financial support has been provided by the Juvenile Diabetes Research Foundation, the University of Calgary Faculty of Medicine, and Calgary Laboratory Services. 6. References Alexander E, Dooley KC, Pohajdak B, & Wright JR Jr. (2006). Things we’ve learned from tilapia islet xenotransplantation.

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Xenotransplantation by S. Miyagawa

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